Jounce Therapeutics Presents Preclinical Data from JTX-8064 Program at the 2019 American Association for Cancer Research (AACR) Annual Meeting
“Today, we presented the characterization of JTX-8064 and the preclinical data for this novel product candidate, demonstrating its potential in re-programming tumor-associated macrophages within the tumor microenvironment to enhance anti-tumor immunity. We believe that LILRB2 functions as an immune checkpoint for macrophages and have demonstrated differentiation from other macrophage-directed approaches,” said
In a poster titled “Preclinical evaluation of JTX-8064, an anti-LILRB2 antagonist antibody, for reprogramming tumor-associated macrophages,” Jounce researchers describe the preclinical evaluation of JTX-8064 including:
- JTX-8064 is a specific and potent antagonist antibody of LILRB2 (leukocyte immunoglobulin like receptor B2; ILT4)
- LILRB2 binds to its ligands (classical MHC I molecules [e.g. HLA-A, HLA-B] and non-classical MHC I molecules [e.g. HLA-G]) and maintains an immuno-suppressive state in macrophages. JTX-8064 blocks ligand binding to LILRB2 and induces an immune activating state in macrophages that may lead to enhancement of the anti-tumor immune response
- Inhibiting LILRB2 induces pro-inflammatory cytokine secretion and a unique transcriptional profile suggestive of an M1-like shift in human macrophages, which is distinct from macrophage-targeted mAbs CSF1R and TIM-3
The poster is available on the “Our Approach” section of the
JTX-8064 is an anti-Leukocyte Immunoglobulin Like Receptor B2 (LILRB2) antibody and is the first candidate to emerge from Jounce’s Translational Science Platform efforts that focuses on tumor-associated macrophages. Preclinical data presented at the 2019 AACR Annual Meeting supports the development of JTX-8064 as a novel immunotherapy to reprogram immune-suppressive macrophages and enhance anti-tumor immunity. JTX-8064 is currently in IND-enabling activities and Jounce anticipates filing an IND and initiating a Phase 1 clinical trial for JTX-8064 in 2019.
Statements in this release concerning Jounce’s future expectations and plans, including without limitation, Jounce’s expectations regarding the timing of filing of an Investigational New Drug application and initiation of a Phase 1 clinical trial of JTX-8064, and Jounce’s clinical development strategy may constitute forward looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995 and other federal securities laws and are subject to substantial risks, uncertainties and assumptions. You should not place reliance on these forward looking statements, which include words such as “believe,” “expect,” “aims,” “anticipates,” “intend,” “may,” “potential” or similar terms, variations of such terms or the negative of those terms. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, the Company cannot guarantee such outcomes. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, as well as those risks more fully discussed in the section entitled “Risk Factors” in Jounce’s most recent annual report on Form 10-K or quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in Jounce’s subsequent filings with the
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Source: Jounce Therapeutics, Inc.